Stuart Little is no ordinary mouse. Born to a family of humans, he lives in New York City with his parents, his older brother, George, and Snowbell the cat. Though he's shy and thoughtful, he's also a true lover of adventure.

When his best friend, a beautiful little bird named Margalo, disappears from her nest, Stuart is determined to track her down. He ventures away from home for the very first time in his life and finds adventure aplenty, but will he find his friend?